diff --git a/core/libs/prx/libkernel/DirectMemory/DirectMemory.cpp b/core/libs/prx/libkernel/DirectMemory/DirectMemory.cpp
index 9eeb24861..8d1916f7b 100644
--- a/core/libs/prx/libkernel/DirectMemory/DirectMemory.cpp
+++ b/core/libs/prx/libkernel/DirectMemory/DirectMemory.cpp
@@ -921,6 +921,10 @@ int DoMprotect(const void* addr, size_t len, int prot) {
         else if (IsGuestModuleImage(memory.AllocationBase)) mutation.RegisterImage(memory.AllocationBase);
         else throw std::invalid_argument("Memory protection of a foreign image is not supported");
     }
+    if (memory.Type == MEM_PRIVATE && memory.State == MEM_COMMIT && memory.RegionSize >= bytes && !mutation.Overlaps(pointer, bytes)) {
+        if (mprotect(const_cast<void*>(pointer), bytes, nativeProtection) != 0) throw std::system_error(errno, std::generic_category(), "mprotect failed");
+        return 0;
+    }
 #else
     mutation.RegisterMainImage();
 #endif
diff --git a/core/libs/tests/GuestMemory.cpp b/core/libs/tests/GuestMemory.cpp
index 74beb7554..427a6d064 100644
--- a/core/libs/tests/GuestMemory.cpp
+++ b/core/libs/tests/GuestMemory.cpp
@@ -1698,12 +1698,31 @@ static void CheckAvailableDirectMemoryIsLargestFreeBlock() {
     Require(sceKernelAvailableDirectMemorySize(top, top + window, 0, &start, &size) == 0);
     Require(start == top && size == static_cast<std::size_t>(window));
 }
+#ifdef _WIN32
+static void CheckMprotectOfHostMemoryOutsideTheGuestRegistry() {
+    constexpr std::size_t length = 0x40000;
+    void* host = VirtualAlloc(nullptr, length, MEM_COMMIT | MEM_RESERVE, PAGE_READWRITE);
+    Require(host != nullptr);
+    Require(sceKernelMprotect(host, length, 0x3) == 0);
+    static_cast<volatile unsigned char*>(host)[length - 1] = 7;
+    Require(static_cast<volatile unsigned char*>(host)[length - 1] == 7);
+    Require(sceKernelMprotect(host, length, 0x1) == 0);
+    MEMORY_BASIC_INFORMATION info{};
+    Require(VirtualQuery(host, &info, sizeof(info)) == sizeof(info) && info.Protect == PAGE_READONLY);
+    Require(sceKernelMprotect(host, length, 0x3) == 0);
+    Require(VirtualQuery(host, &info, sizeof(info)) == sizeof(info) && info.Protect == PAGE_READWRITE);
+    Require(VirtualFree(host, 0, MEM_RELEASE) != 0);
+}
+#endif
 
 int main() {
 #ifdef _WIN32
     _putenv_s("APS5_PIN_WAIT_MS", "1000");
 #endif
     CheckAvailableDirectMemoryIsLargestFreeBlock();
+#ifdef _WIN32
+    CheckMprotectOfHostMemoryOutsideTheGuestRegistry();
+#endif
     CheckVirtualQuerySplitFlexibleRanges();
     CheckVirtualQueryForNonReadableGuestRange();
     CheckReleaseFlexibleMemory();